m i c r o b i o m e c h a n i c s

Welcome to the Tang Lab at University of California, Irvine

Our Research

About Us

The Microbiomechanics Laboratory aims at studying biological systems at the micro- and nano-scales with mechanically-derived modalities. We develop devices and platforms that enable both in-vitro and in-vivo studies of the mechanical aspects in physiological activities involving cells, tissues, and organs. They would be suitable for interfacing and interrogating the mechanical phenomena of interest within the targeted physiological activities at the length-scales that are beyond the reach of traditional biomedical instrumentations. Our vision is that these devices and platforms will:

1. enable new research efforts to understand the significance of biomechanics at the most basic unit of life -the cell.

2. offer clinically-relevant applications that require accurate real-time data on the stress strain distributions in the organs or physiological systems for investigation and diagnosis of the mechanical implications of health and diseases within the organs.

3. leverage the understanding in physiological phenomena researched with these tools to develop prosthetic devices to restore both sensory and motor functions that are mechanical in nature within the body.

µBML News

May 3, 2019
Prof. William Tang was awarded a subcontract from Biopico Systems, Inc., under the NIH SBIR grant to develop "Cellular Electrophysiological Purification Array (CEPA) for Preclinical Therapies." Pictured from left: Dr. Henry Wong (Chief Engineer) and Dr. John Collins (President & CEO) of Biopico Systems, Inc., with Prof. William Tang and his doctoral student Joanne Ly. This work is a synergistical collaboration leveraging the expertise in micro technologies, microfluidics, cellular mechanics, and biomedical applications from both groups.
April 20, 2019
Spring 2019 quarterly social at Irvine Lanes!
March 29, 2019
The Microbiomechanics Laboratory is forging a research collaboration with the Vietnam National Geriatric Hospital, the Irvine Clinical Research, and the OC Alzheimer to address the educational and intervention needs for Vietnamese patients with Alzheimer disease. Together with Dr. Dung Trinh of the Irvine Clinical Research, Dr. Tang and Joanne visited the hospital in Hanoi to discuss the details and plans for collaborative tasks.
March 1, 2019
Prof. Tang was honored with the Professor of the Year Award in Biomedical Engineering during 46th Annual Award Banquet on March 1, 2019 hosted by the Engineering Student Council. Congratulations!
January 26, 2019
The latest 2018 Spring UROP, 2018 SURP, and 2018 E-SURP Fellows have just been announced:

Chrissie Alexander - 2nd time

Rifat Amin - 1st time

Ashley Avila - 1st time

Lillian Chang - 1st time

Steven Chang - 2nd time

Brittanie Chu - 3rd time

Salonee Darbari - 2nd time

Julian Drake - 1st time

Madhumita Kannan - 3rd time

Samuel Lassers - 3rd time

Wendy Lei - 1st time

Zach Siu - 3rd time

Jennifer Tran - 2nd time

Josh Wang - 3rd time

Vienna Wu - 2nd time

Sabrina Yip - 3rd time

Big congratulations!

August 24-26, 2018
Carina Lee won the Best Oral Presentation Paper Award at the 2018 International Conference on Nano Science & Technology (ICNST 2018) in Sapporo, Japan.
June 19, 2018
The latest 2018 Spring UROP, 2018 SURP, and 2018 E-SURP Fellows have just been announced:

Chrissie Alexander - 1st time

Brittanie Chu - 2nd time, including 2017 Fall

Klaudia Cymerska - 1st time

Salonee Darbari - 1st time

Madhumita Kannan - 2nd time, including 2017 Fall

Samuel Lassers - 1st time

Wendy Lei - 1st time

Jonathan Lim - 1st time

Zach Siu - 2nd time, including 2017 Fall

Jennifer Tran - 1st time

Josh Wang - 2nd time, including 2017 Fall

Kaylie Wong - 2nd time, including 2017 Fall

Vienna Wu - 1st time

Sabrina Yip - 2nd time, including 2017 Fall

Big congratulations!

April 13, 2018
We received funding from a private donor to support our research on neuroengineering for clinical applications. Our heart-felt appreciation to the donor who sees the importance of researching engineering approaches to save lives!
January 17, 2018
The latest 2017 Fall UROP Fellows have just been announced:

William Agnew - 6th time, including 2017 Spring, 2016 Fall, 2015 Fall, 2015 SURP and 2015 E-SURP

Brittanie Chu - 1st time

Brandon Jeong - 4th time, including 2017 SURP, 2017 Spring, and 2016 Fall

Madhumita Kannan - 1st time

Samuel Lassers - 1st time

Zach Siu - 1st time

Reese Tobaben - 1st time

Josh Wang - 1st time

Kaylie Wong - 1st time

Sabrina Yip - 1st time

Big congratulations!
January 20, 2017
William Agnew (5th time, including SURP Fellow and E-SURP Fellow 2015),

Hishaam Ali (2nd time),

Christopher Foskett (2nd time),

John Gozal (1st time),

Hanze Hu (1st time),

Brandon Jeong (1st time),

William Kim (2nd time),

Jasmine Llave (1st time),

Zion Lee (3rd time, including E-SURP Fellow 2016),

Guan Yu Liu (1st time),

Selena Saromo (1st time), and

Josh Yeung (1st time)

were appointed Undergraduate Research Opportunities Program (UROP) Fellows for the 2016-2017 academic year druing the Fall Call for Proposals.
December 13, 2016
Prof. William C. Tang was in the news, interviewed and quoted by The Atlantic in the article "Bulletproofing America."
September 30, 2016
Prof. William C. Tang was appointed Hai-Tian Scholar (海天学者) by the Dalian University of Technology (大连理工大学) for a period of three years. Under the program, Prof. Tang is funded to pursue collaborative research with DUT on the subject of Alzheimer's disease.
June 15, 2016
Zion Lee was appointed Edwards Lifesciences Summer Undergraduate Research Program (E-SURP) Fellow.
January 13, 2016
William Agnew (4th time, including SURP Fellow and E-SURP Fellow 2015), Tasnim Ahmed (6th time, including SURP Fellow 2015), Hishaam Ali (1st time), Rui Cao (2nd time), Jullyanne Corpuz (1st time), Christopher Foskett (1st time), Bita Kianian (2nd time), William Kim (1st time), Zion Lee (1st time), Sadaf Mirnia (1st time), Taylor Shen (1st time), Cyril Soliman (3rd time) were appointed Undergraduate Research Opportunities Program (UROP) Fellows for the 2015-2016 academic year druing the Fall Call for Proposals.
June 15, 2015
William Agnew (1st time, also SURP Fellow and E-SURP Fellow 2015), Tasnim Ahmed (4th time, also SURP Fellow 2015), Rui Cao (1st time), Claudia Cetrola (4th time), Ci Ren (2nd time), and Cyril Soliman (2nd time) were appointed Undergraduate Research Opportunities Program (UROP) Fellows for the 2015-2016 academic year druing the Spring Call for Proposals.
January 9, 2015
Tasnim Ahmed (3rd time), Lydia Ameri (4th time), Claudia Cetrola (3rd time), Anthony Han (3rd time), Emily Kha (3rd time), Bita Kianian (1st time), Nick Look (1st time), Ci Ren (1st time), Cyril Soliman (1st time) and Yijiao Wang (4th time) were appointed Undergraduate Research Opportunities Program (UROP) Fellows for the 2014-2015 academic year during the Fall Call for Proposals.
June 30, 2014
Tasnim Ahmed, Lydia Ameri, Claudia Cetrola, Gary Chang, Anthony Han, Emily Kha, and Yijiao Wang were appointed Undergraduate Research Opportunities Program (UROP) Fellows for the 2014-2015 academic year during the Spring Call for Proposals.
May 28, 2014
Claudia Cetrola was appointed Edwards Lifesciences Summer Undergraduate Research Program (E-SURP) Fellow for Summer 2014.
January 20, 2014
Tasnim Ahmed, Lydia Ameri, Gary Chang, Anthony Han, Emily Kha, Michael Lum, Indrani Mikkilineni, Kishan Patel, Aswini Ponnaluri, and Yijiao Wang were appointed the Undergraduate Research Opportunities Program (UROP) Fellows for the 2013-2014 academic year.
January 14, 2014
Prof. William C. Tang and his ex-student, Dr. Yu-Hsiang Hsu, were awarded the U.S. Patent on their malaria detection invention: W. C. Tang and Y.-H. Hsu, “Microfluidic devices and methods for malaria detection,” U.S. Patent #8,628,972, January 14, 2014.
January 15, 2013
Lydia Ameri, Gary Chang, Hanna Chang, Michael Lum, Indrani Mikkilineni, Shravya Nagurla, Andrea Navarro, Kishan Patel, Aswini Ponnaluri, Abdullah Siddiqui, Tracey Tien, and Yijiao Wang were appointed the Undergraduate Research Opportunities Program (UROP) Fellows for the 2012-2013 academic year.
November 5, 2012
Prof. William C. Tang was awarded $1.65m Phase II of the Pricision Rate-Integrating Micro Gyroscope program from DARPA to continue his collaborative research with the MicroSystems Laboratory.
August 2, 2011
Prof. William C. Tang and his students were awarded the U.S. Patent on their neural probe invention: W. C. Tang, J. Wu, and R. Hainley, “High density micromachined electrode arrays useable for auditory nerve implants and related methods,” U.S. Patent #7,991,475, August 2, 2011.
July 20, 2011
Prof. William C. Tang in collaboration with Dr. Alex Trusov (Mechanical and Aerospace Engineering) and Dr. Karl Yee (Jet Propulsion Laboratory) was awarded a grant of over $2.7m by the Defense Advanced Research Projects Agency (DARPA). Prof. Tang as the Principal Investigator will lead this three-year effort to pursue research on Precision Rate-Integrating Micro Gyroscope.
June 24, 2011
Michael Lum, Shravya Nagurla, Andrea Navarro, and Tracey Tien were appointed the Undergraduate Research Opportunities Program (UROP) Fellows for the 2011-2012 academic year.
May 24, 2011
Both Andrea Navarro and Tracey Tien were appointed the Edwards Lifesciences Summer Undergraduate Research Program (E-SURP) Fellows for their poroposal on microplatforms for studying the biomechanics of cardiomyocytes.
January 1, 2011
Prof. William C. Tang was re-appointed as the Associate Dean for Research for the Henry Samueli School of Engineering. At the same time, he has stepped down from the position of Associate Chair for Undergraduate Education for the Biomedical Engineering Department. Details of his Associate Dean appointment can be found at: http://www.eng.uci.edu/node/1424
September 21, 2010
Prof. William C. Tang was awarded the 2010 Fariborz Maseeh Outstanding Faculty Teaching Award during the Annual Dinner and Awards Banquet of the Henry Samueli School of Engineering.
July 1, 2010
Prof. William C. Tang has completed his duties both as Associate Dean for Research for the Henry Samueli School of Engineering and Acting Chair for the Department of Biomedical Engineering. He now takes on the responsibilities of the Associate Chair for Undergraduate Education for the Department.
July 1, 2009
Prof. William C. Tang has assumed the additional role of acting chair for the Department of Biomedical Engineering
March 5, 2008
Prof. William C. Tang has been appointed as the first Associate Dean for Research for the Henry Samueli School of Engineering. His appointment will begin at the start of spring quarter, 2008.
September 8, 2006
The Orange County Chapter of the IEEE Engineering in Medicine and Biology is officially established. Dr. William C. Tang is the founding Chairman of the Chapter.
May 13, 2006
Dr. William C. Tang was given the 2006 Chancellor's Award for Excellence in Undergraduate Research "to recognize the meritorious contributions in support of undergraduate research." "
March 2006
Dr. William C. Tang was elected Fellow of the American Institute for Medical and Biological Engineering for "Significant contribution in the field of BioMEMS and Nano-scale technologies"

Completed Projects